除了小分子抑制剂,核酸技术也开始在ACH治疗中得到应用。Ribomic开发的RBM-007,通过限制FGF2和FGFR3激活变体之间的过度相互作用发挥功能。2期临床结果显示,RBM-007的疗效与Vosoritide相近(1.5厘米/年),甚至有一名受试者年增长5厘米,且该试验中包括2周一次的注射频率,是当前在研药物中最长的给药间隔。
The game server runs at 10 “ticks” a second. Every tick we move and grow players, eat fruit, calculate collisions, and broadcast the new gamestate to clients.
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黎智英欺詐案上訴得直:定罪及刑罰被撤銷,出獄時間提前
One thing that I found really interesting was the ability of the LLM to inspect the COM files for ZEXALL / ZEXCOM tests for the Z80, easily spot the CP/M syscalls that were used (a total of three), and implement them for the extended z80 test (executed by make fulltest). So, at this point, why not implement a full CP/M environment? Same process again, same good result in a matter of minutes. This time I interacted with it a bit more for the VT100 / ADM3 terminal escapes conversions, reported things not working in WordStar initially, and in a few minutes everything I tested was working well enough (but, there are fixes to do, like simulating a 2Mhz clock, right now it runs at full speed making CP/M games impossible to use).